|
KMID : 0858520110150010048
|
|
Journal of the Korean Society of Magnetic Resonance in Medicine
2011 Volume.15 No. 1 p.48 ~ p.56
|
|
|
Measurements of -and -relaxation Time Changes According to the Morphological Characteristics of Gold Nanoparticles (GNPs)
|
|
Jang Moo-Young
Han Yong-Hee
Mun Chi-Woong
|
|
|
Abstract
|
|
|
Purpose: The aim of this study is to measure the typical MR variables such as - and -relaxation times according to morphological characteristics of gold nanopartides as a preliminary study to perform theragnosis using local heating by gold nanopartides.
Materials and Methods: Two types of gold nanoparticles were used. Spheres were synthesized by various methods and stirring speed. Rods were synthesized by adding various concentrations of sphere nanopartides. Gold nanopartides were mixed with 2% agarose gel at 1:1 ratio and then signals were acquired using a 1.5T MRI. For the measurements of -and -relaxation times, TR and TE were varied, respectively. The results were acquired through and curves based on the intensities of MR image using self-developed software. And Statistical analysis was performed.
Results: times were measured 1.86 sec and 2.08 sec for sphere and rod, respectively. On the other hands, times were measured 57 ms and 35.45 ms for sphere and rod.
Conslusion: The changes of the MR variables according to the morphological characteristics of the gold nanopartides were confirmed. Optimal MR imaging conditions can be obtained by choosing proper TR and TE according to the type of nanoparticles.
|
|
|
KEYWORD
|
|
|
Theragnosis, Gold nanoparticle, Magnetic resonance imaging (MRI), -relaxation time, -relaxation time
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|